SMTP Error 550 5.2.1 – Mailbox Unavailable: Causes & Fixes

Illustration of an anthropomorphic tiger with orange fur and black stripes, wearing a black shirt. The tiger has a serious expression and crossed arms, set against a light yellow background.
Smiling person with a beard and short hair against a black background, wearing a black top.
A person with long blonde hair is looking at the camera. They are wearing a black top and are indoors, with a neutral expression and soft lighting.
A person with short hair and a beard wearing a patterned shirt stands outdoors with a sunset in the background. The sky is a gradient of blue, orange, and pink, and a body of water is visible in the distance.
Talk with a
deliverability expert!

Content:

    The number of emails sent and received worldwide per day is predicted to reach 408.2 billion by 2027. This only shows how important people and businesses perceive email as a communication channel.

    One of the most common email deliverability problems that email senders and administrators come across is the SMTP Error 550 5.2.1. The reason for this error message being sent is when an email cannot be delivered as the recipient mailbox is unavailable.

    This can be a big issue for those whose businesses or sales are dependent on email to reach others, like marketing efforts. It may be okay for you to tolerate this mistake once, but this will harm your business in the long run the error continues to occur.

    In this guide, we will help you understand what SMTP Error 550 5.2.1 is, how to check mailbox availability, and actionable suggestions to resolve this error.

    What is SMTP Error 550 5.2.1?

    SMTP stands for Simple Mail Transfer Protocol, which is an industry default standard used to send emails over the internet. When an email message is undelivered, an error message is sent to the sender.

    This SMTP Error 550 5.2.1 points to an issue related to the mailbox of the target receiver. The full error message usually reads something along the lines of “550 5.2.1 Mailbox unavailable.”

    This is one of the SMTP 550 error codes and commonly indicates that the email sent cannot be delivered and is a permanent failure. To be more specific, Error 550 5.2.1 refers to issues with the recipient’s mailbox that prevent the email from being received. 

    Causes of SMTP Error 550 5.2.1

    SMTP Error 550 5.2.1 can be defined by several causes, and they all deal with the status of the mailbox of the recipient. Later on, you will be able to identify the problem and take action based on the specific causes. The most common causes of this error are as follows.

    Mailbox is unavailable

    This might indicate that the mailbox is temporarily out of service, or it is not accepting messages because of issues with the server. There are a variety of reasons where mailboxes may not be available:

    • There is a scheduled server maintenance
    • The email system is experiencing technical glitches
    • The recipient’s email provider has problems (such as server downtime or configuration errors). In these cases, email servers will attempt to deliver the message, but the system cannot accept or store it, resulting in this error.

    Q: What is the difference between SMTP Error 550 5.2.1 and SMTP Error 451 4.5.0 when both error messages say “Mailbox Unavailable?”

    A:  SMTP Error 451 4.5.0 occurs when an email server temporarily rejects a message because the mailbox is not available as a consequence of a number of reasons such as a full inbox, ongoing maintenance, mail flow rate limits or even an authentication failure. SMTP Error 550 5.2.1, on the other hand, indicates an issue on the recipient’s end.  For more information on SMTP Error 451 4.5.0, you can check our resource here.

    Mailbox is over quota

    A mailbox can’t accept new messages when the recipient’s mailbox has filled its storage capacity. Providers typically define how much space an email inbox has. 

    Once the mailbox is full, delivery of any new messages fails with 550 5.2.1 error. Such measures are particularly prevalent among organizations or individuals dealing with high volumes of emails or large email attachments which may consume storage space faster.

    Disabled or suspended mailbox

    A mailbox may also be rejected if it has been disabled or suspended by the mail provider. There can be multiple reasons that led to this, such as not paying the fees, violating the company policy, and inactivity for a long time, security, etc. Here is an example from Gmail, explaining their policies.

    When an email provider deactivates or suspends a mailbox, its mail system will deny further attempts to deliver messages. This reinforces that no emails are still delivered to an inactive or compromised mailbox. Suspension often occurs when an account violates terms of service or when the mailbox has been flagged for security reasons.

    Actionable solutions for fixing SMTP Error 550 5.2.1

    By following these steps, you can resolve the problem and ensure that your emails are successfully delivered to the recipient’s inbox.

    Verify and fix mailbox settings

    The first step in fixing SMTP Error 550 5.2.1 is to verify the status of the recipient’s mailbox. You want to make sure that the mailbox is available and set up correctly, to receive new emails.

    Steps to verify and fix mailbox settings:

    1. Verify mail server logs: Inspect the mail server logs to check if there is any problem with the receiver’s mailbox. If a mailbox is unavailable, the logs may show you if it’s down temporarily (due to a server issue) or misconfigured.
    2. Confirm mailbox availability: Verify the mailbox with the recipient or the email admins. If the mailbox is a third-party hosted provider, check their service status for any ongoing outages. 
    3. Update DNS settings: Make sure the DNS records for the email domain are correctly configured. If the DNS records (like MX records) are incorrect or misconfigured, the mailbox will be unavailable. 

    Q: What are DNS records and why are they important for deliverability?

    A: DNS records are essential system settings that map domain names to specific IP addresses. This helps email servers identify and authenticate the sender’s domain. Properly configured DNS records are vital for improving email deliverability and building sender trust.

    Check mailbox quota and increase capacity

    If the issue is caused by a mailbox being over quota, you’ll need to check the storage usage of the mailbox and either free up space or increase the capacity to resolve the problem.

    Steps to check mailbox quota and increase capacity:

    1. Check storage usage: Have the recipient check the usage of the mailbox. Most email providers—such as Gmail or Outlook—will show current storage usage at the bottom of your inbox or in the account settings.
    2. Clear space: If the mailbox is full, guide the recipient to delete unnecessary emails, especially those containing large attachments. There’s a movement called “inbox detox” advocating regular inbox cleaning. Another option is to archive old emails, or move them to an external storage location such as Google Drive.
    3. Increase mailbox capacity: If the recipient’s mailbox regularly fills up, they may want to consider upgrading the storage plan with their email provider. There are premium plans available on many email services with a higher storage limit and that can support more data.

    Fix disabled mailboxes

    In case the mailbox of the recipient has been disabled or suspended then it will be necessary to fix the suspension or re-enable the mailbox in order to restore email functionality.

    Steps to fix disabled mailboxes:

    1. Contact the recipient or provider: You might see a sudden spike in bounced emails or a total black hole when delivering to a certain recipient. In these scenarios, you can confirm whether the mailbox is not suspended or the domain is decommissioned, which can be done by contacting the recipient or the email provider. If they have no clue, tell them to contact their email service provider.
    2. Re-enable the mailbox: When a mailbox has been deactivated as a result of inactivity or other policy violations, the recipient must follow the provider’s steps to reactivate the account. This can be checking identity, paying outstanding bills or correcting other problems the provider raised.
    3. Look for temporary suspension: In cases where the mailbox has been temporarily suspended for security or violation of terms of service, the recipient may need to rectify this by following the steps provided by their email service provider or contacting support.

    Warmy.io—an all-in-one solution to optimize deliverability success for senders

    Although SMTP Error 550 5.2.1 is usually a result of problems with the recipient, there are things senders can do on their end to maximize email deliverability. Plus, confirming that everything is working on the senders’ side makes things easy when spending time finding out why a SMTP error happened in the first place.

    Warmy.io is a powerful tool that helps improve sender reputation, avoid spam filters, and ensure emails reach inboxes. Let’s look at some of its key features that help optimize email deliverability:

    Email deliverability testing to diagnosing issues proactively

    Warmy’s free email deliverability test helps senders get a comprehensive view of the current state of their deliverability and sender reputation. Since there are many reasons behind email delivery failures, the email delivery test essentially checks if everything is working and optimized on your end. For example: 

    • Senders will get to see where emails land (Inbox, Spam, or Promotions) across providers like Gmail, Outlook, and Yahoo, plus the corresponding percentages. This enables senders to verify if certain SMTP errors are caused by something on their end.
    • Email senders can also check if their domain or IP is blacklisted. That way, they can resolve it before it starts impacting performance. 

    SPF, DKIM, and DMARC verification helps ensure proper email authentication to improve trust and reduce deferrals.

    AI-powered email warmup gradually builds sender reputation

    Sender reputation is a huge factor that impacts the deliverability of your emails. Warmy.io’s AI-powered email warmup ensures that your domain is gradually introduced to email service providers without triggering spam filters. By doing so, it prevents the sudden spikes in email volume that often lead to rejections and flags from ESPs. 

    The warmup process mimics human behavior with your emails—taking actions such as opening, scrolling, and clicking—making your emails appear organic to ESPs and improving your reputation. Moreover, the solution is one of the most powerful because it allows sending up to 5,000 emails a day. It also includes custom templates and multiple language support to tailor the experience.

    Overall, Warmy’s AI-powered email warmup provides senders a solid foundation for future outreach efforts and campaigns. 

    Warmup preferences gives senders customized control over email warmup

    A dashboard displaying a profile section with a circular chart titled WARM-UP PREFERENCES. The chart shows percentages for Gmail, Outlook, G-Suite, Yahoo, and others. A table beneath lists specific percentages and email services.

    Warmy’s new Warmup Preferences feature allows users to customize and fully control the warmup process from both sender and user levels to optimize deliverability further. Here is a quick snapshot of what this feature can deliver for your deliverability:

    • Sender-level customization: This feature enables users to set a granular level of targeting based on specific email providers (e.g., Gmail, Microsoft 365, Outlook, etc.). You can even define the percentage of emails sent to each provider so that your warmup process matches your target audience
    • User-level customization: For users managing multiple mailboxes, Warmy offers a streamlined approach to adjust settings across all accounts simultaneously. This makes it easier to maintain consistent and optimized deliverability settings.
    • Audience targeting: Users can choose between B2B or B2C engagement patterns, so the warmup process is tailored to the nature of their business and email campaigns.
    • Visibility and transparency: Senders will get full visibility into mailbox balancing and warmup preferences so they can monitor and adjust their settings easily.

    Advanced seed lists for real engagement and improved sender reputation

    Warmy offers the most advanced email seed lists that offer actual engagement—your emails are opened, scrolled through, clicked on, and replied to. If there are emails that land in spam, these are removed and marked as important to let the ESPs know you are credible. These signals show ESPs that your emails are trustworthy, engaging, and relevant to recipients—effectively strengthening your reputation over time.

    A beige interface displays options for selecting the number of seeds and senders with a slider and buttons. Below, a table compares features of Gmail, Outlook, and Yahoo seeds with checkmarks for various actions.

    This advanced approach to seed lists makes Warmy.io a highly effective tool for ensuring better email engagement and deliverability. Learn more about Warmy’s seed lists here. And if you may want to get a deeper look at how Warmy’s seed lists work and what they can do for your email deliverability, you can check out our latest resources:

    Achieve optimal email deliverability with Warmy.io

    It’s true that SMTP Error 550 5.2.1 can significantly impede your email campaigns, but by utilizing Warmy.io’s suite of features, senders can greatly improve their email deliverability. 

    From customized warm-up preferences to advanced seed lists and comprehensive deliverability testing, Warmy empowers businesses to optimize their sender reputation, avoid spam filters, and ensure that emails consistently land in inboxes. 

    While SMTP Error 550 5.2.1 is often unavoidable due to issues on the recipient’s end, senders can confidently execute their campaigns knowing everything is optimized on their side. Try Warmy.io for free today—and start your journey to stronger sender reputation and successful deliverability.

    Picture of Daniel Shnaider

    Article by

    Daniel Shnaider

    Picture of Daniel Shnaider

    Article by

    Daniel Shnaider

    An icon depicting a closed white envelope resting in an open, empty white tray with a blue interior background.

    Get the week’s
    best marketing content

      *You can unsubscribe anytime
      An icon depicting a closed white envelope resting in an open, empty white tray with a blue interior background.

      Get the week’s
      best marketing content

        *You can unsubscribe anytime

        Related Post

        SMTP Error 554 5.4.6 “Too Many hops” is one of the most common errors faced by email administrators. It happens

        You’ve crafted the perfect email campaign, targeted your audience, and hit “send.” But then, an unsettling notification appears in your

        It is a fact: Email communication is one of the most important aspects of daily business and personal interactions. On

        If your emails are suddenly bouncing back with SMTP Error 421 4.7.28, your IP address has been temporarily blocked by

        Scroll to Top